It is completely unclear, how cytosolic FUS and TDP43 inclusions arise and apart from p62 and ubiquitin, no other cellular markers or coaggregating proteins have been detected within these inclusions (Neumann et al, 2006, 2007, 2009a; Kwiatkowski et al, 2009; Vance et al, 2009). As the inclusions occur predominantly in the cytosol, defects in nucleocytoplasmic transport or enhanced aggregation in the cytosol may lead to cytoplasmic mislocalization of TDP43 and FUS. This may interfere with their physiological nuclear function or cause a toxic gainoffunction because of excessive accumulation in the cytoplasm..In 2010, he returned to Kansas City and spent a weekend with foster youth and community leaders. Smith's involvement is a reason Kansas City's Cornerstones of Care, an organization that works with foster children, has partnered with a church to create a similar scholarship program. The partnership has allowed 12 disadvantaged teens to attend college..

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