michael kors outlet Here we survey available data concerning the role of autoreactive immunoglobulins in neurotoxicity. A generally accepted view of MS pathogenesis has linked the disease process to myelinspecific, CD4 T lymphocytes which, upon activation by unknown factors, migrate through the blood barrier (BBB), engage CNSrelated antigenic peptides presented by antigen presenting cells, clonally expand, and exert cytotoxic attacks on oligodendrocytes and myelin. This hypothesis has been largely driven by observations from the experimental autoimmune encephalomyelitis (EAE) model that represents a demyelinating CNS disorder mediated by myelinspecific CD4 T cells.2, 3However, recent histological analyses4 and in vivo studies by magnetic resonance imaging (MRI) and spectroscopy (MRS)5, 6 emphasize that neurodegeneration develops along with inflammatory demyelination.Trusting in the process of life and trusting your own wisdom. Filling your