When GWB came into office we were creating jobs and when he left we were losing 750,000 jobs a month and the economy went into a ditch. Worst jobs loss since the Great Depression due to a Republican president and republican policies of tax cuts and deregulation. Wall Street needs more regulation..Top of pageAbstractThe regulation of cellular metabolism and survival by trophic factors is not completely understood. Here, we describe a signaling cascade activated by the developmental regulator Notch, which inhibits apoptosis triggered by neglect in mammalian cells. In this pathway, the Notch intracellular domain (NIC), which is released after interaction with ligand, converges on the kinase mammalian target of rapamycin (mTOR) and the substratedefining protein rapamycin independent companion of mTOR (Rictor), culminating in the activation of the kinase Akt Biochemical and molecular approaches using sitedirected mutants identified AktS473 as a key downstream target in the antiapoptotic