Neurofascinspecific antibodies can also inhibit remyelination by binding to NF155 expressed on the surface of oligodendrocytes.Gangliosides Another group of neuronal antigens includes the gangliosides, which are glycolipids with sialic residues in the outer layer of cell membranes. Gangliosides are particularly enriched in the membranes of neuron. To generate antibody responses, gangliosides do not require major histocompatibility complex (MHC) molecules and Tcell help.75 Although it is unclear whether antiganglioside antibodies can cause or result from axonal damage,18 they may certainly serve as a marker of this process.According to a BU official, the NIH annually provides roughly $21 million in funding to the Framingham study, some of which funds multiyear grants. Of that, some $10 million is sent by the NHLBI to Boston University for basic infrastructure needs and grants for ancillary studies. But sequestration has chopped that account down to $5.9 million..

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