The identification of TDP43 as the major protein in the neuropathological hallmark lesions of patients with frontotemporal lobar degeneration with ubiquitinated inclusions (FTLDU, meanwhile renamed to FTLDTDP (Mackenzie et al, 2009)) and in amyotrophic lateral sclerosis (ALS) emphasizes the importance of TDP43 (Neumann et al, 2006). Distinct neuropathological profiles distinguish particular subtypes of sporadic and familial FTLDU and ALS, with TDP43 immunoreactivity being present in dystrophic neurites and neuronal cytoplasmic inclusions as well as in neuronal intranuclear inclusions (Kwong et al, 2007). Moreover, TDP43positive cytosolic aggregates in muscle cells have been described in familiar or sporadic inclusion body myopathies (IBM) (Weihl et al, 2008; Oliv et al, 2009)..The problem, at least according to Public Citizen, is that the standard in Virginia isn clearly defined by that law. Appeals courts in the state have not previously considered this question, but Public Citize